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Apprentice Mode
10 Modules / ~100 pages
Wizard Mode
~25 Modules / ~400 pages

Advanced Organic Synthesis
( 25 Modules )

Module #1
Introduction to Advanced Organic Synthesis
Overview of the importance of organic synthesis, recent advances, and course objectives.
Module #2
Stereochemistry in Organic Synthesis
Review of stereochemical principles, diastereoselectivity, and enantioselectivity in organic reactions.
Module #3
Organometallic Reagents in Organic Synthesis
Introduction to organometallic reagents, their preparation, and applications in organic synthesis.
Module #4
Transition Metal-Catalyzed Coupling Reactions
Mechanism and applications of Heck, Suzuki, Sonogashira, and Stille reactions.
Module #5
C-C Bond Forming Reactions:Aldol and Related Reactions
Mechanism, stereochemistry, and applications of aldol, Claisen, and related reactions.
Module #6
C-C Bond Forming Reactions:Alkyne and Alkene Metathesis
Mechanism, stereochemistry, and applications of alkyne and alkene metathesis reactions.
Module #7
C-H Bond Functionalization Strategies
Introduction to C-H bond functionalization, mechanisms, and applications in organic synthesis.
Module #8
Oxidation Reactions in Organic Synthesis
Mechanism, stereochemistry, and applications of oxidation reactions, including epoxidation and dihydroxylation.
Module #9
Reduction Reactions in Organic Synthesis
Mechanism, stereochemistry, and applications of reduction reactions, including hydrogenation and hydride transfer.
Module #10
Organocatalysis in Organic Synthesis
Introduction to organocatalysis, mechanism, and applications in asymmetric synthesis.
Module #11
Chirality Transfer and Asymmetric Catalysis
Mechanism, stereochemistry, and applications of chirality transfer and asymmetric catalysis.
Module #12
Macrocyclic Compounds:Synthesis and Applications
Introduction to macrocyclic compounds, synthesis strategies, and applications in supramolecular chemistry.
Module #13
Heterocyclic Compounds:Synthesis and Applications
Introduction to heterocyclic compounds, synthesis strategies, and applications in medicinal chemistry.
Module #14
Total Synthesis of Natural Products
Case studies of total synthesis of natural products, including retrosynthesis and strategy development.
Module #15
Synthetic Methodologies for Peptide and Glycopeptide Synthesis
Introduction to peptide and glycopeptide synthesis, including solid-phase and solution-phase methods.
Module #16
Synthetic Methodologies for Carbohydrate Synthesis
Introduction to carbohydrate synthesis, including glycosylation and protecting group strategies.
Module #17
Synthetic Methodologies for Nucleic Acid Synthesis
Introduction to nucleic acid synthesis, including phosphoramidite and H-phosphonate methods.
Module #18
Computational Tools in Organic Synthesis
Introduction to computational tools, including DFT and molecular mechanics, for predicting reaction outcomes.
Module #19
Green Chemistry Principles in Organic Synthesis
Introduction to green chemistry principles, including atom economy, and their applications in organic synthesis.
Module #20
Process Development and Scale-up in Organic Synthesis
Introduction to process development and scale-up considerations, including safety and regulatory aspects.
Module #21
Advanced Analytical Techniques in Organic Synthesis
Introduction to advanced analytical techniques, including NMR, MS, and chromatography, for structure elucidation and reaction monitoring.
Module #22
Synthetic Strategies for Complex Molecules
Case studies of synthetic strategies for complex molecules, including biomimetic and biomolecule-inspired approaches.
Module #23
Stereocontrolled Synthesis of Complex Molecules
Case studies of stereocontrolled synthesis of complex molecules, including polyketides and polyenes.
Module #24
Organic Synthesis in Industry:Challenges and Opportunities
Overview of the challenges and opportunities in organic synthesis in industry, including process development and manufacturing.
Module #25
Course Wrap-Up & Conclusion
Planning next steps in Advanced Organic Synthesis career


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