Biochemical Basis of Drug Resistance
( 25 Modules )

Module #1
Introduction to Drug Resistance
Overview of the problem of drug resistance, importance of understanding biochemical basis of drug resistance

Module #2
Mechanisms of Drug Action
Enzyme inhibition, receptor binding, and other mechanisms of drug action

Module #3
Evolution of Drug Resistance
Principles of evolution, selection pressure, and genetic variation

Module #4
Types of Drug Resistance
Intrinsic, acquired, and cross-resistance, including examples

Module #5
Cell Wall Biosynthesis and Beta-Lactam Resistance
Biochemistry of peptidoglycan synthesis, beta-lactam antibiotics, and mechanisms of resistance

Module #6
DNA Replication and Quinolone Resistance
Biochemistry of DNA replication, quinolone antibiotics, and mechanisms of resistance

Module #7
Protein Synthesis and Aminoglycoside Resistance
Biochemistry of protein synthesis, aminoglycoside antibiotics, and mechanisms of resistance

Module #8
Folate Biosynthesis and Antifolate Resistance
Biochemistry of folate synthesis, antifolate antibiotics, and mechanisms of resistance

Module #9
Sterol Biosynthesis and Azole Resistance
Biochemistry of sterol synthesis, azole antifungals, and mechanisms of resistance

Module #10
Efflux Pumps and Multidrug Resistance
Structure and function of efflux pumps, mechanisms of multidrug resistance

Module #11
Target Modification and Antibiotic Resistance
Mutations in target enzymes, altered target binding, and antibiotic resistance

Module #12
Enzymatic Inactivation of Antibiotics
Beta-lactamases, aminoglycoside-modifying enzymes, and other mechanisms of enzymatic inactivation

Module #13
Cell Membrane Permeability and Antibiotic Uptake
Cell membrane structure and function, antibiotic uptake, and resistance mechanisms

Module #14
Gene Regulation and Antibiotic Resistance
Transcriptional regulation of antibiotic resistance genes, two-component systems

Module #15
Horizontal Gene Transfer and Antibiotic Resistance
Mechanisms of horizontal gene transfer, role in antibiotic resistance

Module #16
Biochemical Basis of Antibiotic Resistance in Bacteria
Examples of antibiotic resistance in bacteria, including MRSA, TB, and E. coli

Module #17
Biochemical Basis of Antibiotic Resistance in Fungi
Examples of antibiotic resistance in fungi, including Candida and Aspergillus

Module #18
Biochemical Basis of Antibiotic Resistance in Protozoa
Examples of antibiotic resistance in protozoa, including Plasmodium and Leishmania

Module #19
New Targets and Strategies for Antibacterial Therapy
Novel targets and approaches for antibacterial therapy, including anti-virulence and anti-biofilm strategies

Module #20
New Targets and Strategies for Antifungal Therapy
Novel targets and approaches for antifungal therapy, including inhibitors of fungal cell wall and ergosterol biosynthesis

Module #21
Combination Therapy and Antibiotic Resistance
Rationale and strategies for combination therapy to combat antibiotic resistance

Module #22
Pharmacokinetic/Pharmacodynamic (PK/PD) Considerations
PK/PD principles and their impact on antibiotic resistance

Module #23
Antibiotic Resistance and the Microbiome
Impact of antibiotic resistance on the human microbiome, consequences for health and disease

Module #24
Clinical and Epidemiological Aspects of Antibiotic Resistance
Clinical and epidemiological factors contributing to antibiotic resistance, surveillance and monitoring

Module #25
Course Wrap-Up & Conclusion
Planning next steps in Biochemical Basis of Drug Resistance career

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Biochemical Basis of Drug Resistance ( 25 Modules )

Biochemical Basis of Drug Resistance
( 25 Modules )