Downstream Processing in Biochemical Engineering
( 30 Modules )

Module #1
Introduction to Downstream Processing
Overview of downstream processing, importance, and challenges in biochemical engineering

Module #2
Harvesting and Recovery of Biomolecules
Methods for harvesting and recovering biomolecules from fermentation broths

Module #3
Cell Disruption and Lysis
Methods for disrupting and lysing cells to release intracellular biomolecules

Module #4
Centrifugation and Sedimentation
Principles and operation of centrifuges and sedimentation tanks

Module #5
Filtration and Microfiltration
Principles and operation of filtration and microfiltration systems

Module #6
Ultrafiltration and Diafiltration
Principles and operation of ultrafiltration and diafiltration systems

Module #7
Chromatography Principles
Introduction to chromatography, types, and principles

Module #8
Gel Filtration Chromatography
Principles and operation of gel filtration chromatography

Module #9
Ion Exchange Chromatography
Principles and operation of ion exchange chromatography

Module #10
Hydrophobic Interaction Chromatography
Principles and operation of hydrophobic interaction chromatography

Module #11
Affinity Chromatography
Principles and operation of affinity chromatography

Module #12
Crystallization and Precipitation
Methods for crystallization and precipitation of biomolecules

Module #13
Drying and Lyophilization
Methods for drying and lyophilization of biomolecules

Module #14
Sterilization and Aseptic Processing
Methods for sterilization and aseptic processing of biomolecules

Module #15
Process Scale-Up and Validation
Challenges and strategies for process scale-up and validation

Module #16
Downstream Processing of Specific Biomolecules
Case studies of downstream processing of specific biomolecules (e.g. proteins, antibodies, vaccines)

Module #17
Integration of Upstream and Downstream Processing
Importance and strategies for integrating upstream and downstream processing

Module #18
Economic and Environmental Impact of Downstream Processing
Economic and environmental impact of downstream processing and strategies for sustainability

Module #19
Downstream Processing in Industry
Challenges and opportunities in industrial downstream processing

Module #20
Future Directions in Downstream Processing
Emerging trends and technologies in downstream processing

Module #21
Regulatory Aspects of Downstream Processing
Regulatory requirements and guidelines for downstream processing

Module #22
Downstream Processing in Biomanufacturing
Role of downstream processing in biomanufacturing and biopharmaceutical production

Module #23
Advanced Separation Technologies
Emerging advanced separation technologies for downstream processing

Module #24
Single-Use Technologies in Downstream Processing
Role and applications of single-use technologies in downstream processing

Module #25
Continuous Downstream Processing
Principles and applications of continuous downstream processing

Module #26
Modeling and Simulation in Downstream Processing
Applications of modeling and simulation in downstream processing

Module #27
Automation and Control in Downstream Processing
Importance and applications of automation and control in downstream processing

Module #28
Quality Control and Assurance in Downstream Processing
Role and importance of quality control and assurance in downstream processing

Module #29
Troubleshooting in Downstream Processing
Strategies and approaches for troubleshooting in downstream processing

Module #30
Course Wrap-Up & Conclusion
Planning next steps in Downstream Processing in Biochemical Engineering career

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Downstream Processing in Biochemical Engineering ( 30 Modules )

Downstream Processing in Biochemical Engineering
( 30 Modules )