Genetic Mutations and Disease Mechanisms
( 25 Modules )

Module #1
Introduction to Genetic Mutations
Overview of genetic mutations, types, and frequency; importance in human disease

Module #2
Molecular Basis of Genetic Mutations
DNA structure, replication, and repair; mechanisms of mutation occurrence

Module #3
Types of Genetic Mutations
Point mutations, frameshift mutations, chromosomal mutations, and epigenetic modifications

Module #4
Mutagenesis and Environmental Factors
Environmental agents that induce mutations, such as radiation and chemicals

Module #5
Genetic Mutation Detection and Diagnosis
Methods for detecting genetic mutations, including PCR, sequencing, and microarrays

Module #6
Single Gene Disorders
Mendelian inheritance, penetrance, and expressivity; examples of single gene disorders

Module #7
Cystic Fibrosis:A Case Study
Genetic and molecular mechanisms of cystic fibrosis, diagnosis, and treatment

Module #8
Mendelian Disorders of the Nervous System
Huntingtons disease, spinocerebellar ataxias, and other neurological disorders caused by single gene mutations

Module #9
Cancer Genetics
Genetic mutations in cancer, oncogenes, tumor suppressor genes, and DNA repair genes

Module #10
Tumor Suppressor Genes and Cancer
Examples of tumor suppressor genes, such as p53 and BRCA1/2

Module #11
Oncogenes and Cancer
Examples of oncogenes, such as HER2 and RAS

Module #12
Complex Traits and Polygenic Disorders
Genetic and environmental factors contributing to complex traits, such as diabetes and heart disease

Module #13
Genome-Wide Association Studies (GWAS)
Methodologies and applications of GWAS in understanding complex traits

Module #14
Epigenetics and Disease
Epigenetic mechanisms, such as DNA methylation and histone modification, in disease

Module #15
Mitochondrial Genetics and Disease
Mitochondrial DNA mutations and their role in human disease

Module #16
Gene-Environment Interactions and Disease
Interplay between genetic and environmental factors in disease causation

Module #17
Pharmacogenomics and Personalized Medicine
Genetic variations and drug response, pharmacogenomic approaches to personalized medicine

Module #18
Gene Therapy and Genome Editing
Principles and applications of gene therapy and genome editing technologies, such as CRISPR/Cas9

Module #19
Regulatory Genomics and Disease
Regulatory elements, such as enhancers and promoters, in disease pathogenesis

Module #20
Stem Cells and Disease Modeling
Use of stem cells in modeling human disease, including genetic disorders and cancer

Module #21
Computational Tools for Genomic Analysis
Bioinformatic tools and methods for analyzing genomic data

Module #22
Genomic Data Interpretation and Variant Analysis
Interpretation of genomic data, including variant annotation and functional prediction

Module #23
Genetic Counseling and Risk Assessment
Genetic counseling principles, risk assessment, and communication of genetic information

Module #24
Ethical and Social Implications of Genetic Research
Ethical considerations in genetic research, including genetic privacy and discrimination

Module #25
Course Wrap-Up & Conclusion
Planning next steps in Genetic Mutations and Disease Mechanisms career

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Genetic Mutations and Disease Mechanisms ( 25 Modules )

Genetic Mutations and Disease Mechanisms
( 25 Modules )