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Apprentice Mode
10 Modules / ~100 pages
Wizard Mode
~25 Modules / ~400 pages

Pharmacokinetics and Pharmacodynamics
( 25 Modules )

Module #1
Introduction to Pharmacokinetics and Pharmacodynamics
Overview of PK/PD principles, importance in drug development and therapy
Module #2
Pharmacokinetic Concepts
Definition of pharmacokinetics, ADME process (absorption, distribution, metabolism, excretion)
Module #3
Pharmacodynamic Concepts
Definition of pharmacodynamics, receptor theory, dose-response relationships
Module #4
Absorption Mechanisms
Passive and active transport, bioavailability, factors affecting absorption
Module #5
Distribution Kinetics
Volume of distribution, distribution half-life, protein binding, compartment models
Module #6
Metabolism and Biotransformation
Phase I and Phase II reactions, enzyme induction and inhibition, drug-drug interactions
Module #7
Excretion Mechanisms
Renal excretion, hepatic excretion, biliary excretion, enterohepatic circulation
Module #8
PK Modeling and Simulation
Compartment models, non-compartment models, model validation, simulation techniques
Module #9
PD Modeling and Simulation
Direct and indirect PD models, sigmoidal Emax model, IC50 and EC50
Module #10
PK/PD Integration
Linking PK and PD models, PK/PD modeling in drug development
Module #11
Dose-Response Relationships
Graded and quantal responses,potency and efficacy, dose-response curves
Module #12
Receptor Theory and Pharmacology
Receptor types, agonists and antagonists, partial agonism and inverse agonism
Module #13
Enzyme Kinetics and Inhibition
Michaelis-Menten kinetics, competitive and non-competitive inhibition, IC50 and Ki
Module #14
Pharmacogenomics and Personalized Medicine
Genetic variability in PK and PD, pharmacogenetic testing, personalized therapy
Module #15
PK/PD in Special Populations
Pediatric and geriatric populations, renal and hepatic impairment, pregnancy and lactation
Module #16
Drug Interactions and Polypharmacy
Pharmacokinetic and pharmacodynamic interactions, drug-drug interactions, polypharmacy and adverse effects
Module #17
PK/PD in Drug Discovery and Development
Lead optimization, candidate selection, PK/PD in clinical trials
Module #18
Regulatory Aspects of PK/PD
FDA and EMA guidelines, PK/PD data in regulatory submissions
Module #19
PK/PD in Biotherapeutics
Large molecule PK/PD, immunogenicity and antibody-drug conjugates
Module #20
PK/PD in Cancer Therapy
Tumor pharmacology, chemotherapeutic agents, targeted therapies and immunotherapy
Module #21
PK/PD in Infectious Diseases
Antimicrobial PK/PD, resistance and susceptibility testing, antibacterial and antiviral therapy
Module #22
PK/PD in Pain Management
Opioid pharmacology, pain pathways, PK/PD of analgesics
Module #23
PK/PD in Cardiovascular Diseases
Cardiovascular pharmacology, hypertension, dyslipidemia and atherosclerosis
Module #24
PK/PD in Neurology and Psychiatry
Neurotransmission, neuropharmacology, PK/PD of CNS drugs
Module #25
Course Wrap-Up & Conclusion
Planning next steps in Pharmacokinetics and Pharmacodynamics career


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