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Apprentice Mode
10 Modules / ~100 pages
Wizard Mode
~25 Modules / ~400 pages

Protein Folding and Misfolding Mechanisms
( 24 Modules )

Module #1
Introduction to Protein Folding
Overview of protein structure, importance of protein folding, and mechanisms of protein misfolding
Module #2
Primary and Secondary Protein Structure
Review of amino acid sequences, peptide bonds, and secondary structures (alpha helices, beta sheets)
Module #3
Tertiary and Quaternary Protein Structure
Folding into 3D structures, domains, and interactions between subunits
Module #4
Thermodynamics of Protein Folding
Free energy landscapes, folding pathways, and equilibrium constants
Module #5
Kinetics of Protein Folding
Folding rates, transition states, and kinetic intermediates
Module #6
Molecular Chaperones and Folding Assistants
Role of chaperones in facilitating protein folding and preventing misfolding
Module #7
Protein Misfolding and Aggregation
Introduction to protein misfolding, aggregation, and amyloid formation
Module #8
Misfolding Mechanisms:Hydrophobic Interactions
Role of hydrophobic interactions in protein misfolding and aggregation
Module #9
Misfolding Mechanisms:Electrostatic Interactions
Role of electrostatic interactions in protein misfolding and aggregation
Module #10
Misfolding Mechanisms:Disulfide Bonds and Oxidative Stress
Role of disulfide bonds and oxidative stress in protein misfolding and aggregation
Module #11
Amyloid Formation and Toxicity
Mechanisms of amyloid formation, toxicity, and implications for disease
Module #12
Prion Proteins and Infectious Misfolding
Prion proteins, infectious misfolding, and implications for disease
Module #13
Protein Misfolding and Disease:Alzheimers and Parkinsons
Role of protein misfolding in Alzheimers and Parkinsons diseases
Module #14
Protein Misfolding and Disease:Huntingtons and ALS
Role of protein misfolding in Huntingtons disease and Amyotrophic Lateral Sclerosis (ALS)
Module #15
Protein Misfolding and Cancer
Role of protein misfolding in cancer development and progression
Module #16
Computational Methods for Protein Folding and Misfolding
Introduction to computational methods for simulating protein folding and misfolding
Module #17
Molecular Dynamics Simulations
Principles and applications of molecular dynamics simulations for protein folding and misfolding
Module #18
Experimental Methods for Studying Protein Folding and Misfolding
Overview of experimental techniques for studying protein folding and misfolding
Module #19
Circular Dichroism and Fluorescence Spectroscopy
Applications of circular dichroism and fluorescence spectroscopy for studying protein folding and misfolding
Module #20
NMR Spectroscopy and Mass Spectrometry
Applications of NMR spectroscopy and mass spectrometry for studying protein folding and misfolding
Module #21
Electron Microscopy and Atomic Force Microscopy
Applications of electron microscopy and atomic force microscopy for studying protein folding and misfolding
Module #22
Therapeutic Strategies for Protein Misfolding Diseases
Overview of therapeutic strategies for protein misfolding diseases, including small molecules and biologics
Module #23
Protein Misfolding and Biotechnology
Applications of protein misfolding in biotechnology, including protein engineering and design
Module #24
Course Wrap-Up & Conclusion
Planning next steps in Protein Folding and Misfolding Mechanisms career


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