Module #1 Introduction to Protein-Protein Interactions Overview of protein-protein interactions, their importance in biological systems, and significance in biomedical research
Module #2 Types of Protein-Protein Interactions Classification of PPIs, including obligate, non-obligate, and transient interactions
Module #3 Protein Structure and Function Review of protein structure, function, and evolution, highlighting their impact on PPIs
Module #4 Protein-Protein Interaction Networks Introduction to PPI networks, visualization tools, and analysis methods
Module #5 Detecting Protein-Protein Interactions Overview of high-throughput methods for detecting PPIs, including yeast two-hybrid, co-immunoprecipitation, and mass spectrometry
Module #6 Protein-Protein Interaction Databases Survey of popular PPI databases, including IntAct, BioGRID, and STRING
Module #7 Scoring and Predicting Protein-Protein Interactions Introduction to scoring functions and machine learning-based methods for predicting PPIs
Module #8 Molecular Docking and Simulation Principles of molecular docking and simulation, with applications to PPI prediction and optimization
Module #9 Protein-Protein Interaction Hotspots Identification and characterization of hotspots, including their roles in PPI binding and regulation
Module #10 Allosteric Regulation of Protein-Protein Interactions Mechanisms of allosteric regulation, including conformational changes and binding site cooperativity
Module #11 Post-Translational Modifications and Protein-Protein Interactions Impact of PTMs on PPIs, including phosphorylation, ubiquitination, and acetylation
Module #12 Protein-Protein Interaction Dynamics Experimental and computational approaches to studying PPI dynamics, including NMR, FRET, and MD simulations
Module #13 Membrane-Protein Interactions Specialized aspects of PPIs at the membrane interface, including membrane protein structure and function
Module #14 Protein-Protein Interactions in Diseases Roles of PPIs in disease pathology, including cancer, neurodegenerative disorders, and infectious diseases
Module #15 Targeting Protein-Protein Interactions for Therapeutics Strategies for modulating PPIs for therapeutic benefit, including small molecules and biologics
Module #16 Computational Tools for Protein-Protein Interaction Analysis Hands-on training with popular tools, including PyMOL, Chimera, and Cytoscape
Module #17 Case Studies in Protein-Protein Interaction Research In-depth analysis of landmark studies and recent breakthroughs in PPI research
Module #18 Emerging Topics in Protein-Protein Interactions Recent advances and future directions in PPI research, including single-molecule studies and artificial intelligence
Module #19 Protein-Protein Interaction Modeling and Simulation Advanced topics in modeling and simulation of PPIs, including coarse-grained models and machine learning
Module #20 Data Integration and Visualization in Protein-Protein Interaction Analysis Methods for integrating and visualizing large-scale PPI data, including network analysis and visualization tools
Module #21 Protein-Protein Interactions in Systems Biology Integrating PPIs into systems-level models, including flux balance analysis and dynamic modeling
Module #22 Protein-Protein Interactions in Synthetic Biology Designing and engineering PPIs for synthetic biological systems, including biosensors and gene circuits
Module #23 Protein-Protein Interactions in Biotechnology Applications of PPIs in biotechnology, including biofuel production and bioremediation
Module #24 Protein-Protein Interactions in Personalized Medicine Role of PPIs in personalized medicine, including cancer precision medicine and genetic counseling
Module #25 Protein-Protein Interaction Ethics and Policy Ethical and policy implications of PPI research, including gene editing and biosecurity
Module #26 Computational Methods for Protein-Protein Interaction Prediction Advanced computational methods for PPI prediction, including machine learning and deep learning
Module #27 Protein-Protein Interaction in Immunology PPIs in the immune system, including antigen-antibody interactions and immune cell signaling
Module #28 Protein-Protein Interaction in Neurobiology PPIs in the nervous system, including synaptic plasticity and neurological disorders
Module #29 Protein-Protein Interaction in Cancer Biology PPIs in cancer development and progression, including tumor suppressor and oncogenic interactions
Module #30 Course Wrap-Up & Conclusion Planning next steps in Protein-Protein Interactions career
