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Apprentice Mode
10 Modules / ~100 pages
Wizard Mode
~25 Modules / ~400 pages

Protein Structure-Function Relationships
( 24 Modules )

Module #1
Introduction to Protein Structure-Function Relationships
Overview of protein structure and function, importance of understanding structure-function relationships
Module #2
Primary Structure:Amino Acid Sequence and Properties
Amino acid chemistry, peptide bond formation, and primary structure determination methods
Module #3
Secondary Structure:Alpha Helices and Beta Sheets
Helix and sheet formation, stabilizing interactions, and prediction methods
Module #4
Tertiary Structure:3D Folding and Domain Architecture
Protein folding, domain classification, and structural motifs
Module #5
Quaternary Structure:Protein-Protein Interactions and Oligomerization
Quaternary structure definition, protein-protein interaction interfaces, and oligomerization mechanisms
Module #6
Protein Folding and Misfolding:Thermodynamics and Kinetics
Protein folding mechanisms, thermodynamic and kinetic aspects, and misfolding consequences
Module #7
Structural Analysis Techniques:X-ray Crystallography and NMR Spectroscopy
Introduction to X-ray crystallography and NMR spectroscopy, data collection, and structure determination
Module #8
Bioinformatics Tools for Protein Structure Analysis
Protein structure prediction, sequence alignment, and database searching
Module #9
Enzyme Structure and Function:Active Sites and Catalysis
Enzyme active sites, substrate binding, and catalytic mechanisms
Module #10
Protein-Ligand Interactions:Binding Affinity and Specificity
Ligand binding modes, binding affinity, and specificity determinants
Module #11
Allosteric Regulation:Conformational Changes and Signaling
Allosteric regulation mechanisms, conformational changes, and signaling pathways
Module #12
Membrane Protein Structure and Function:Transmembrane Helices and Transport
Membrane protein structure, transmembrane helices, and transport mechanisms
Module #13
Structural Basis of Protein-Membrane Interactions
Protein-membrane interactions, membrane binding motifs, and lipophilic interactions
Module #14
Nuclear Magnetic Resonance (NMR) Spectroscopy for Protein Structure
NMR spectroscopy principles, protein structure determination, and dynamics analysis
Module #15
Cryo-Electron Microscopy (Cryo-EM) for Protein Structure
Cryo-EM principles, protein structure determination, and sample preparation
Module #16
Molecular Dynamics Simulations:Protein Structure and Dynamics
Molecular dynamics simulations, force fields, and protein structure and dynamics analysis
Module #17
Protein Engineering:Design and Optimization of Protein Function
Protein engineering principles, design strategies, and optimization methods
Module #18
Protein-Protein Interactions:Prediction and Analysis
Protein-protein interaction prediction, analysis, and network construction
Module #19
Structural Basis of Human Diseases:Protein Misfolding and Aggregation
Protein misfolding and aggregation in human diseases, such as Alzheimers and Parkinsons
Module #20
Computational Methods for Protein Structure Prediction
Computational methods for protein structure prediction, including threading, fragment-based methods, and machine learning
Module #21
Protein Design:De Novo Design and Redesign of Proteins
De novo protein design, protein redesign, and optimization of protein function
Module #22
Single-Molecule Studies:Protein Function and Dynamics
Single-molecule techniques, protein function, and dynamics analysis
Module #23
Protein Structure and Function in Cellular Context
Protein structure and function in cellular context, including protein-protein interactions and signaling pathways
Module #24
Course Wrap-Up & Conclusion
Planning next steps in Protein Structure-Function Relationships career


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