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Apprentice Mode
10 Modules / ~100 pages
Wizard Mode
~25 Modules / ~400 pages

Structural Biology for Protein Design
( 25 Modules )

Module #1
Introduction to Protein Design
Overview of protein design, importance, and applications
Module #2
Protein Structure and Function
Basic principles of protein structure, function, and folding
Module #3
Primary and Secondary Structure
Amino acid properties, primary sequence, and secondary structure elements
Module #4
Tertiary and Quaternary Structure
3D protein structure, protein-protein interactions, and quaternary structure
Module #5
Protein Folding and Stability
Thermodynamic and kinetic aspects of protein folding, stability, and misfolding
Module #6
Introduction to Structural Biology
Overview of structural biology methods and their applications in protein design
Module #7
X-Ray Crystallography
Principles and applications of X-ray crystallography in protein structure determination
Module #8
Nuclear Magnetic Resonance (NMR) Spectroscopy
Principles and applications of NMR spectroscopy in protein structure determination
Module #9
Cryogenic Electron Microscopy (Cryo-EM)
Principles and applications of Cryo-EM in protein structure determination
Module #10
Molecular Modeling and Simulation
Introduction to molecular mechanics, dynamics, and simulation methods
Module #11
Protein Sequence Analysis
Methods for analyzing and predicting protein sequences, including motif detection and phylogenetics
Module #12
Protein Structure Prediction
Methods for predicting protein structure from sequence, including ab initio and template-based modeling
Module #13
Molecular Docking and Binding
Principles and methods for predicting protein-ligand interactions and binding affinity
Module #14
Protein-Protein Interactions
Methods for predicting and designing protein-protein interactions
Module #15
Enzyme Design
Principles and methods for designing enzymes with improved catalytic activity and specificity
Module #16
Protein Stability and Solubility Engineering
Methods for improving protein stability and solubility
Module #17
Directed Evolution for Protein Design
Principles and methods for using directed evolution to design proteins with improved properties
Module #18
Rational Protein Design
Principles and methods for rational design of proteins with improved function and stability
Module #19
Computational Tools for Protein Design
Overview of computational tools and software for protein design, including Rosetta and FoldX
Module #20
Case Studies in Protein Design
Real-world examples of successful protein design projects, including enzyme design and stability engineering
Module #21
Protein Design for Biomedical Applications
Applications of protein design in biomedicine, including vaccine design and antibody engineering
Module #22
Protein Design for Biotechnological Applications
Applications of protein design in biotechnology, including biofuels and biosensors
Module #23
Ethical Considerations in Protein Design
Ethical implications of protein design, including biosafety and biosecurity concerns
Module #24
Future Directions in Protein Design
Emerging trends and opportunities in protein design, including machine learning and artificial intelligence
Module #25
Course Wrap-Up & Conclusion
Planning next steps in Structural Biology for Protein Design career


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